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Second, incubation with Cu(II) leads to formation of spherical ubiquitin aggregation, and this process is inhibited by Cu(II) chelation or reduction to Cu(I) (Santoro et al., 2016)

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Once the production of the (e)ine/GSH/GPX4 axis is inhibited, lethal amounts of LPO will accumulate, resulting in disruptions such as cell membrane rupture, cell swelling, mitochondrial rupture and leading to ferroptosis (Shan et al., 2023)