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Figure1: Stages of vitiligo and poliosis over a one-year period After initial phone consultation by the referring veterinarian with the ophthalmologist, the dog was begun on a regimen of oral prednisone and azathioprine (Imuran)

The nasal mucosa provides a rich blood supply, a large surface area of approximately 150 square centimeters, and direct access to systemic circulation without hepatic first-pass metabolism

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Common techniques include click chemistry (e.g., azide-alkyne reactions), thiol-maleimide coupling, and EDC/NHS-mediated amide bond formation, all of which exploit naturally occurring or introduced reactive groups like amines or thiols on EV surfaces (Fig