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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

Excessive doses of vitamin B6 over a prolonged period can cause sensory neuropathy leading to muscle weakness

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Editorial: Exploring the need to include microbiomes into EFSA's scientific assessments

Caregiver burden and its relationship to health-related quality of life in craniopharyngioma survivors