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Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task

Ann Thorac Surg 89(1):210-1, 2010

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According to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition, text revision ( DSM-5 -TR), opioid withdrawal watery discharge from the eyes or nose goose flesh, or goosebumps pain diarrhea nausea, vomiting, or both dilated pupils sensitivity to light insomnia rapid breathing rapid heart rate heightened reflexes high blood pressure high body temperature sweating yawning A person may also experience long-term symptoms, such as: anxiety sleep problems persistent fatigue a general feeling of being unwell drug cravings Most of these can last for several months, but a craving for drugs can last for years

2014": Rapid tumor regrowth resumed as soon as therapy was discontinued, whereas combination therapy with the HIF1 inhibitor digoxin prevented BCSC enrichment and resulted in tumor eradication (Samanta et al, 2014)

demonstrated that anti-angiogenic therapy with anti-VEGFR2 enhances the efficacy of anti-PD-L1 immunotherapy in pancreatic neuroendocrine tumor (RT2-PNET), mammary carcinoma (MMTV-PyMT), and glioblastoma (NFpp10-GBM) models 88