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The drug is entrapped within the solid lipid matrix, leading to a slower release through diffusion as the NP gradually erodes or the drug partitions out of the lipid matrix

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Furthermore, similar analysis were observed in transgenic models of PD under different promoters, with reports of motor impairment and behavioral dysfunction in (Thy-1)-h[A30P] -syn mice and (Thy-1)-h[A53T] -syn mice (Ekmark-Lewen et al., 2018) (Table 1)

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Pretreatment with PGG (100 or 200 mg/kg, orally) for 8 days prior to the administration of indomethacin furnished significant reductions in gastric mucosal lesions as well as a significant increase in mucus concentration