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PD PD is the second most common neurodegenerative disorder and the most prevalent neurodegenerative movement disorder, affecting approximately 1% of individuals over 60 years of age [79]

In contrast, an arrestin is involved in hDOR internalization but not desensitization upon DPDPE (Aguila et al., 2003b) while upon DPDPE exposure, the receptor is mainly targeted to lysosomes for degradation (Marie et al., 2003b) probably by a mechanism involving GASP (Whistler et al., 2002)

doi:10.1016/j.freeradbiomed.2008.10.040 Tsai CC, Chen HS, Chen SL, Ho YP, Ho KY, Wu YM, Hung CC (2005) Lipid peroxidation: a possible role in the induction and progression of chronic periodontitis

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For IS correlating with declining eGFR (117), two scenarios exist: (1) Reverse causationreduced GFR impairs IS clearance, elevating levels independent of pathogenic effects

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