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a 2025 literature review identified limited clinical evidence, including a retrospective study of 12 patients with knee pain and a Phase I trial in healthy volunteers whose results were not submitted

Morgan DL, Ortiz C (2011): Nuclear, Biologic & Chemical Agents

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265,266 In addition, Trx and thioredoxin-interacting protein (TXNIP), a negative regulator, constitute a redox-like protein compound (redoxisome) that regulates a variety of redox-sensitive signals and is essential for maintaining the intracellular and extracellular redox balance and monitoring inflammatory responses

66 Lifestyle modifications, including reducing purine-rich food intake, maintaining a healthy weight, and engaging in regular physical activity, are crucial for preventing or managing HU