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Trends Endocrinol Metab (2017) 28(3):18698

Proliferating bacteria metabolize a large amount of cysteine and glutathione, and the substrate required for GPX4 is depleted by rapidly growing bacteria ( 3.2.2 Ferritinophagy Attenuated Salmonella infection simultaneously activates NCOA4-dependent ferritinophagy ( 3.3 Autophagy and apoptosis 3.3.1 Autophagy: the balance between survival and death Autophagy plays a dual role during attenuated Salmonella infection

Over activation of glutamate receptors and the resulting Ca 2+ overload stimulates calpains which target cytoskeletal proteins, kinases and phosphatases, membrane receptors and transporters (Xu et al., 2009

However, using this knowledge we expect the formation of a hydroxyl group adjacent to the disulphide bond (as seen in product 7) as well as a peptide break after the oxidation of peroxide 5

FIGURE 3 The Lee group designed a novel hybrid anticancer prodrug (OSamp) that amplifies oxidative stress by depleting GSH and generating ROS (Han et al., 2017)

Vedam SS, Kini VR, Keall PJ, Ramakrishnan V, Mostafavi H, Mohan R