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doi: 10.2174/1381612825666190215121712

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The merging of these signaling pathways plays a massive role in inducing stem cell characteristics, i.e., the ability to self-renew, survive, and resist chemotherapy (Fig

Upregulation of oxidative mitochondrial metabolism is an accepted method of resistance to other therapeutic interventions in various diseases, such as pancreatic cancer and acute myeloid leukaemia 67,68