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For example, tumor cells may avoid the effect of drugs by changing their metabolic pathways, such as surviving by upregulating alternative amino acid metabolic pathways after using HIF-2 inhibitors, or resisting the oxidative stress caused by treatment by enhancing specific metabolic pathways (such as the synthesis of antioxidant glutathione) ( 5.3 Insufficient evidence in the real world and the urgent need for cross-centre standardisation There are still two core obstacles to translating findings on metabolic reprogramming into clinical practice