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Relation of Plasma Indoxyl Sulfate Levels and Estimated Glomerular Filtration Rate to Left Ventricular Diastolic Dysfunction

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Qi, X., Schmiege, P., Coutavas, E., Wang, J

As a key biomarker in urinary system diseases, TMAO suppresses Megalin expression via PI3K and ERK signaling, activates the MAPK-NLRP3 pathway to induce renal oxidative stress and inflammation, and ultimately leads to renal fibrosis

3.4 Health benefits of polyphenols Polyphenols have garnered significant attention due to their potential health benefits, primarily attributed to their antioxidant, anti-inflammatory, and antimicrobial properties (Figure 1)