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This balance influences numerous redox-regulated cellular processes, including the modulation of signaling pathways, post-translational modifications such as protein glutathionylation, activation of transcription factors like Nrf2 and NF-B, and the regulation of cell fate decisions such as proliferation or apoptosis [38]

Herein, we provide evidence that hepatic GSSG accumulation, which was observed in a high-fat diet (HFD)-fed model of NAFLD, rendered hepatocytes susceptible to TNF-induced cell death

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3d,e reveal a pronounced increase in various imc and imf in AA compared to NC

Sci Rep 9(1):2003 Karin M, Yamamoto Y, Wang QM (2004) The IKK NF-kappa B system: a treasure trove for drug development