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Proc Natl Acad Sci U S A, 2002

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A recent study has indicated the increased expression of genes involved in matrix degradation, hypoxia-responsive, and inflammatory signaling in damaged cartilages comparing with healthy counterparts through whole genome microarray analysis, suggesting potential involvement of HIF-1 during the progression of OA pathophysiology (Yudoh et al., 2005

Polgreen PM, Comellas AP

The resulting average crystallite size was found to be approximately 23 nm, suggesting nanoscale grain formation with reasonably uniform distribution