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Surprisingly, extensive down-regulation of miRNAs such as miR-27a, miR-34a, miR-142-5p, and miR-7, involved in cytoprotection against OS and some of them also capable of targeting Nrf2 directly, has been detected in the muscle, CSF, MN progenitors, and blood as well as in post mortem specimens (brain, brain stem, and the spinal cord) of both sALS and fALS patients, unlike healthy controls [258,259,260,261,262]

4.2 Antipsychotic Agents Clinically significant drug interactions between antipsychotic agents and COVID-19 agents, especially with ritonavir-boosted PIs, were documented in healthy volunteers and in patients without COVID-19

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