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Clark WM, Williams BJ, Selzer KA, Zweifler RM, Sabounjian LA, Gammans RE

Wu F, et al

FIGURE 5 Within the co-enriched arginine and proline metabolism pathway, the upregulation of PYCR3 (encoding pyrroline-5-carboxylate reductase) and downregulation of PH4A1 (proline hydroxylase) collectively contributed to elevated intracellular proline levels (Figure 5B)