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These localized reactions typically resolve quickly

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In addition, we collected gross photographs of abdominal aortic aneurysms from four groups (Figure 7B) , and by determining abdominal aortic aneurysm diameters, we found that abdominal aortic aneurysms were significantly more severe in the AD+Vector group than in the Ctrl+Vector group, indicating successful modelling, while abdominal aortic aneurysm diameters were significantly reduced in the AD+sh-RBM15 group compared with the AD+Vector group (Figure 7D)

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Rare reports of hospitalization and/or dialysis or fatal outcome occurred in patients with underlying moderate to severe renal impairment or with any of the risk factors described in this section [see Adverse Reactions (6.2)]