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DLG1 supports T cell activation by interacting with the TCR (T-cell receptor) signaling complex via the kinase Lck, facilitating actin polymerization, NFAT (nuclear factor of activated T-cells) activation, and cytokine production through the p38 MAPK pathway [129, 130] (Fig

Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes

Briefly, IDO, originating from brain cells and from the immune system, together with tryptophan 2,3-dioxygenase (TDO), from the liver, is responsible for converting tryptophan, an essential amino acid precursor of serotonin, into kynurenine

10.1016/j.bioactmat.2024.12.022 75 ZhengJ.DaiB.WangJ.XiongZ.YangY.LiuJ.et al (2017)

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