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This receptor-mediated signaling pathway causes an elevation in the activity of tyrosinase and other enzymes involved in melanogenesis, ultimately giving rise to the hyperpigmentation typically linked to melasma [92,93]

10.1186/1550-2783-9-36 [PMC free article: PMC3441850] [PubMed: 22853297] [CrossRef] Sigala DM, Hieronimus B, Medici V, Lee V, Nunez MV, Bremer AA, et al

The plasma peak concentration of monoethyl phthalate is achieved within 0.75-0.92 h, and monoethyl phthalate is primarily excreted via urine [1]

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Indeed, electrophilic nitro-fatty acids which are formed via nitric oxide or nitrite-dependent redox reactions have been shown to exert antiinflammatory actions (Khoo and Freeman, Statements Acknowledgments Writing of this article was supported by the National Institute of Environmental Health Sciences, National Institutes of Health (RO1 Award ES016959 to Jesus A

If significant interaction effects were detected, data were presented separately by sex with relevant post-hoc analyses (Supplementary Table 1)