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(Bubenek et al., 2012) reported a robust association between NNMT expression, serum MNAM levels, and the onset and progression of peripheral arterial occlusive disease

Two possible explanations for this effect are proposed: (1) reduced food intake due to an irritant effect of the treatment on the gastrointestinal tract (255, 256) or (2) a stimulant effect of TTFD on metabolism via enhanced noradrenaline secretion and thermogenesis (257)

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Roussel, R., Fezeu, L., Bouby, N., Balkau, B., Lantieri, O., Alhenc-Gelas, F., Marre, M., Bankir, L., & Group, for the D