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found after acupuncture treatment in PD mice, a reduction in Proteobacteria in the gut, indicating decreased TMAO levels (Jang et al., 2020) (Figure 8)

Elevated TMAO levels have been linked to a number of diseases, including cardiovascular and neurological disorders, renal disease, metabolic syndrome, obesity, type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), cancer, and severe COVID-19

In these mice, a significant reduction in the number of c-Fos-positive orexin neurons, hypothalamic prepro-orexin mRNA expression, and orexin-A concentration in the cerebrospinal fluid (CSF) was observed [19], [21]

Thymoquinone (2-Isoprpyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: chemistry and biological effects

ASD is likely to affect the entire family of the person diagnosed with this disorder due to a significant level of stress associated with the permanency of this disorder, the accompanying co-morbidities, and insufficient health support for autistic patients [8, 9]

National Institute of Neurological Disorders and Stroke