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The KYN/TRP ratio was positively correlated with the disease activity index SLEDAI [48]

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Biochem Cell Arch 20:27272733 Alsadee SAA (2021) Hepato-nephroprotective role of Lepidium sativum against oxidative stress induced by dexamethasone in rats

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Unbalanced TRP degradation across the KYN pathway, accompanied by the release of potentially neurotoxic metabolites, has been already implicated in many mental illnesses (45, 49, 51)

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