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Traditional treatments like topical creams and light chemical peels only affect the epidermis, which is why they have limited impact on true acne scarring

Technium Soc Sci J 34:136157

Protein kinase C pathway Hyperglycemia-induced activation of the protein kinase C (PKC) pathway represents a critical mechanism in T2DM that associates metabolic disturbances to impaired vascular signaling and cardiovascular complications