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1 Introduction Vascular dementia (VD) is a neurodegenerative disorder associated with chronic cerebral hypoperfusion (CCH), characterized by memory impairment, cognitive decline, and behavioral changes (Pendlebury et al., 2019)

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4C), indicating that the AMPK/mTOR/ULK1 signalling pathway plays a key role in Col-induced HBc degradation

( E ) ImageJ quantification of soft agar colony growth (averaged optical density per well) in all four conditions expressed as relative to mCherry low