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This study also centered on PGC-1s impact on mitochondrial biogenesis, while disregarding effects on mitophagy

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Struyfs, C., Cammue, B., and Thevissen, K., Front

Patients who stick with these often see more steady progress

GPX4 knockdown keratinocytes appeared to have a decreased capacity for cell adhesion, along with accumulating lipid peroxides and enhanced levels of various pro-inflammatory elements, including COX-2, 4-HNE, and prostaglandins (Sengupta et al., 2013)

However, a significant limitation across many studies is the reliance on in vivo phenotypic readouts without robust in vitro mechanistic validation, making it difficult to distinguish direct immunomodulatory effects from secondary consequences