2 Ferroptosis and its link to DCM Ferroptosis is a form of programmed cell death driven by the excessive accumulation of iron ions within cells, triggering the Fenton reaction, activating oxidative stress, and disrupting lipid metabolism, ultimately leading to cellular demise ( Acyl-CoA synthetase long-chain family member 4 (ACSL4) is a key enzyme involved in the synthesis of polyunsaturated fatty acid phosphatidylethanolamine (PUFA-PE) ( In patients with DCM, the GSH-dependent antioxidant mechanism is suppressed, whereas ACSL4 activation promotes ferroptosis in myocardial cells ( In the development of DCM, sustained hyperglycemia acts as a key driver of ferroptosis
Although IF is linked to processes like autophagy, hormonal changes, and enhanced insulin sensitivity, the exact biological mechanisms that make IF safe and work are not fully understood
In patients with moderate or severe liver injury, prednisolone should be administered with discontinuation of the causative drug
(PubMed) Bonvicini M, Travaglini S, Lelli D, Antonelli Incalzi R, Pedone C
30 , 13331339 (2006) Prabhakar, R., Vreven, T., Morokuma, K., Musaev, D.G.: Elucidation of the mechanism of selenoprotein glutathione peroxidase (GP x )-catalyzed hydrogen peroxide reduction by two glutathione molecules: a density functional study
In addition to speeding up recovery, IV therapy can also enhance energy levels and reduce fatigue, which are common after surgery or during prolonged illnesses
