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Their data indicated the importance of targeting the tumor microenvironment by blocking epigenetic mechanisms, which control critical events for colonization such as HGF/c-Met axis as a potential therapy of bone metastasis [40]

[61] provided a final proof of concept

A Phase I/II Study of Pomalidomide and Dexamethasone with Growth Factor Support in Patients with Relapsed/Refractory Multiple Myeloma

E., Ronksley, P

J Biol Chem 286(33):2887628888 Kinlough CL, Poland PA, Bruns JB, Hughey RP (2005) Gamma-glutamyltranspeptidase: disulfide bridges, propeptide cleavage, and activation in the endoplasmic reticulum

Conversely[6] who studied biomarkers of oxidative stress and heavy metal (including lead and zinc) levels as indicators of environmental pollution in some selected fishes in Lagos, Nigeria, reported increased levels of MDA in liver of fishes caught from polluted sites as compared to control sites and attributed this to the pollution of the test site