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A key redox-signaling pathway present in microglia is the NF-B pathway

Both can facilitate the breakdown of misfolded proteins by catalytic mechanisms, such as the generation of ROS or the stimulation of cellular enzymes responsible for removing proteins

doi: 10.3389/fphar.2026.1798309 Received 28 January 2026 Revised 27 February 2026 Accepted 28 February 2026 Published 26 March 2026 Volume 17 - 2026 Edited by Marcos Roberto De Oliveira, Federal University of Rio Grande do Sul, Brazil Reviewed by Maria Jos De Rosa, CONICET Baha Blanca, Argentina Shubham Teli, BVVS Hanagal Shri Kumareshwar College of Pharmacy, India Updates Copyright 2026 Juthi, Ansari, Ahmed, Khan, Seidel, Kumar, Kumari, McKillop, Abdel-Wahab and Flatt

Acknowledgments Heilongjiang Provincial Key Laboratory of Microecology-Immunomodulatory Networks and Related Diseases;The third unit in the end thanks: Heilongjiang Province North medicine and functional food characteristic discipline project

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10.1016/j.redox.2018.01.008 22 CostantinoC