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SKU: 51732225474
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Tissue Regeneration: Activates progenitor cells, reduces apoptosis, and regulates actin polymerization (PubMed 22074294)

Compared with control mice, in mice deficient in the ASK1 gene, prolonged exposure to Ang II initiates a reduction in cardiomyocyte apoptosis, decreased hypertrophy, attenuated upregulation of hypertrophy-related mRNAs, and diminished pathological changes such as interstitial fibrosis and coronary remodeling [247, 248]