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Multicenter, double-blind, vehicle-controlled trial of topical isotretinoin 0.05% gel (N = 268)

Two components contribute to CAI

This is seen from both the transcriptomics studies and the ROS determination

Larger stones, and stones that fail to pass or cause especially severe pain or obstruction and infection may require more aggressive therapies such as antibiotics, lithotripsy (therapy utilizing ultrasound shock waves to break stones into smaller fragments), or surgery to remove stones (Antonelli 2015)