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It typically presents as progressive Parkinsonism and motor dysfunction, including bradykinesia, rigidity, dysarthria, dystonia, gait and coordination disturbances, tremor, and, in severe cases, prominent psychotic symptoms 258

Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity

doi: 10.1016/S1474-4422(24)00086-3 8

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Building on this approach, Lus group developed YF135 , a reversible covalent PROTAC in which the fluoroacrylamide moiety of MRTX849 was replaced with a cyanoacrylamide warhead 33