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Here, we show that HIV infection of macrophages results in survival of a small population of infected cells that are metabolically altered and characterized by mitochondrial fusion, lipid accumulation, and reduced mitochondrial ATP production

Assessment of endothelial dysfunction: The determination of endothelial dysfunction was performed according to the method described by Celemajer et al

Wells were then washed with PBS and collected by trypsinization

Thus, ET-1 induced an EMVs phenotype that negatively affects endothelial cell function [97]

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Several approaches may be considered in developing drugs for reversing aberrant DNA methylation like inhibition of the universal methyl group donor SAM, downregulation of methyl-CpG binding domain (MBD) proteins and inhibition of DNMT enzymes (3538)