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For this reason, make sure to avoid vitamin B12-fortified foods that are sold or stored in clear containers or plastic bags (10)

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Discussion Although many antidepressants with different mechanisms are being used, a number of patients have not achieved appropriate therapeutic effects

When liver enlargement secondary to enzyme induction exceeds an adaptive response, there is hepatotoxicity

Because the active transport system is saturable, absorption will be less efficient at higher concentrations of intake, but the intake levels at which absorptive efficiency decreases in humans are not known

Phase I metabolism is characterized by functionalization of the drug via one or more of the reactions: Oxidation (electron removal, dehydrogenation, or oxygenation) Reduction (electron addition, hydrogenation, or removal of oxygen) Hydration/dehydration (hydrolysis, and addition or removal of water) These transformations are carried out in the endoplasmic reticulum of hepatocytes and the most prominent Phase I reactions are oxidations