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Nies M, Vassilopoulou-Sellin R, Bassett RL, Yedururi S, Zafereo ME , Cabanillas ME, Sherman SI, Links TP, Waguespack SG

Taylor 1 , Yong See Foo 2 , Michael T White 1 1 Department of Global Health, Institut Pasteur, Universit Paris Cit, Paris, France

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No direct kidney damage from tirzepatide has been documented in the SURMOUNT trials

Therapeutic interventions targeting the mechanisms of ferroptosis to prevent RM might also include enhancing GPX4 activity, replenishing GSH levels to reduce lipid peroxidation in decidual stromal cells, utilizing ferroptosis inhibitors such as liproxstatin-1, and modulating ferroportin expression to decrease iron accumulation and promote a successful pregnancy outcome (Sun et al., 2023)

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