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Cerebral glucose uptake is reduced in patients, with distinct metabolic patterns observed across genetic backgrounds (SOD1, C9ORF72, and sporadic ALS), suggesting region-specific vulnerabilities 13

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The formation of ice crystals can physically damage the delicate protein structure of a peptide, a process called denaturation

Oka S, Okabe M, Tsubura S, Mikami M, Imai A

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