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Such heterogeneity complicates the development of universally effective therapies and underscores the need for personalized approaches, which currently face limitations due to an incomplete understanding of these individual determinants (164)

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It also reduces the intramitochondrial ratio of acetyl-CoA to free CoA, which in turn stimulates pyruvate dehydrogenase activity and promotes pyruvate oxidation

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Pycnogenol has been shown to exert anti-inflammatory and antithrombotic effects (26) by inhibiting Cox-1 and Cox-2 enzymatic activity (27), both involved in the inflammatory pathway

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