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Notably, certain plant-derived metabolites activate neuroprotective signaling pathways, such as the MAPK/NF-B system, (Md et al., 2021), and interact with estrogen receptor beta (ER), a known regulator of synaptic plasticity and neuroprotection (Cardona-Gmez et al., 2006)

Key patient-related factors are systemic conditions such as poorly controlled diabetes, peripheral neuropathy, disorders causing tissue hypoxia, connective tissue diseases, malnutrition or obesity, alcohol or illicit drug use, smoking, corticosteroid therapy, and inadequate adherence to treatment protocols

Together, this combination is commonly used in regenerative and recovery-focused protocols to support musculoskeletal repair, soft tissue healing, and overall recovery

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Sources of vitamin D are fish, eggs, and fortified foods