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The theoretical rationale is that L-carnitine's role in fatty acid metabolism might complement Mounjaro's effects on weight reduction and metabolic health

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The majority of the carnitine in American diets comes from foods of animal origin

The enzyme carnitine palmitoyltransferase II (CPT II) which is localized in the inner mitochondrial membrane converts acylcarnitines back to acyl CoAs and free L-carnitine, which exits the mitochondria and serves as the substrate for CPT I to form more acylcarnitine [1, 43]

Next, we observed CD37KO lymphoma cells to be highly responsive to palmitate via increased mitochondrial oxygen consumption rate (OCR), in contrast to WT lymphoma cells (Fig