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Am J Physiol 258:L308L312 Westin MA, Hunt MC, Alexson SE (2005) The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes

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Hcy self-oxidation generates ROS, disrupts redox homeostasis, and induces neuronal apoptosis via upregulation of Bax protein expression and activation of the caspase-3 pathway ( MMA further contributes to oxidative stress by impairing the mitochondrial respiratory chain complexes and energy metabolism

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