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Abstract Type 2 diabetes mellitus (T2DM) is significantly associated with oxidative stress, resulting from the imbalance between reactive oxygen species (ROS) production and antioxidant defenses

doi: 10.1038/s41598-018-29774-z 8 LeeSYCabralHJAschengrauAPearceEN

doi: 10.1042/BSR20211696 55

Indeed, the expression of a c-GPx4 transgene in GPx4 -/- mice rescued the homozygous knockout phenotype by restoring embryonic viability whereas transgenic m-GPx4 expression failed to restore embryonic viability