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Moreover, despite the considerable pre-clinical efficacy of several pharmacological agents targeting pathological events of hemorrhagic stroke, they failed to perform in clinical trials as factors such as the short half-life periods of agents and the role of the blood-brain barrier (BBB) complicated the scenario (Grysiewicz et al., 2008)

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Patients were randomized to apply glutathione as 2% GSSG lotion and a placebo lotion in a split-face protocol, twice daily for ten weeks

doi: 10.2337/db18-1783-P 395 Roszczyc-OwsiejczukKZabielskiP

Winkler G, Pal B, Nagybeganyi E, Ory I, Porochnavec M, Kempler P