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Be Transparent Explain why these changes are happening and what the FDAs rules are

Up-regulation of the levels of androgen receptor and its mRNA by androgens in smooth-muscle cells from rat penis

This, in turn, especially at extremely high concentrations, has been noticed to induce modications of different molecules, including DNA [ 159 ] and proteins [ 160 ], which ultimately can be one of the major contributors in the pathogenesis of various neurodegenerative diseases [ 161 ]