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Once oxidised, glutathione penetration is more challenging and also oxidised glutathione has less efficacy as compared to the reduced glutathione

Moreover, cytokines secreted by macrophages modulate the activity of intracellular LOX, thereby inducing ferroptosis

doi: 10.1002/glia.20686 277 PetrelliF.DallracG.PucciL.CalC.ZehnderT.SultanS.et al

AUAG and CGAA codons were prioritized due to low background

Autoxidation of dehydrogenases, catechols, thiols, flavins, and oxidases, as well as UV radiation, can also generate superoxide anion and hydrogen peroxide