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GG (2 effect alleles): associated with higher risk for lower B12 levels, which can reduce methionine synthase activity, raise homocysteine, and increase reliance on the BHMT backup pathway

studied the effect of selenium deficiency on the radiation-induced renal toxicity using a mice model (Table 2) [45]

Increased levels of lipid ROS and upregulated ferroptosis-related protein expression, which further led to an increase in the type collagen II expression and a decrease in the MMP-13 expression, were also observed under these conditions

& Jefferson, L

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Shi, Y., Burn, P., & Lipworth, B