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These mechanisms include changes in microbial composition, immune activation, vagus nerve signaling, and the production of specific microbial neuroactive metabolites (197)

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Additionally, Nrf2 knockout mice are more sensitive to mitochondrial complex inhibitors such as MPTP and 3-nitropropionic acid [108], suggesting an important role of this transcription factor in scavenging free radicals

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The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids