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Redox-Dependent Modifications of Keap1 as Molecular Switch in PD Keap1 interacts with several other redox-sensitive signaling pathways that modulate the activity of the NLRP3 inflammasome

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[DOI] [PubMed] [Google Scholar] 396.Travaline JM, Sudarshan S, Roy BG, Cordova F, Leyenson V, Criner GJ

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In contrast, the relatively fast oxidation rate of OxyR combined with its slow reduction kinetics eases the sustained oxidation of the transcription factor upon mild to severe H 2 O 2 threats, so that OxyR is maintained in the active form long enough to exert its antioxidant role as a transcription factor