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A recessive S174X mutation in optineurin causes amyotrophic lateral sclerosis through a loss of function via allele-specific nonsense-mediated decay

doi: 10.1016/j.cell.2022.09.023 175 YiuGRasmussenTKTsaiBLDiepVKHaddonDJTsoiJet al

The tolerability of the preparation was very good, and patient compliance was correspondingly high

5b) and four subdomains of motor symptoms (Extended Data Fig

The Se and vitamin E doses and formulations used in SELECT were found to be ineffective, and concern was raised about a possible trend in developing type 2 diabetes mellitus among the study participants taking Se [27]