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Cheignon C, Tomas M, Bonnefont-Rousselot D, Faller P, Hureau C, Collin F

Downstream effects via the active metabolite Pro-Gly-Pro, BDNF and NGF mRNA upregulation, and enkephalinase inhibition persist for 12 to 24 hours, which is why dosing frequency is set by downstream windows rather than plasma kinetics

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One of the reasons for myocardial hypertrophy may be related to the decrease in K+ repolarization associated with the M3 muscarinic ACh receptor, which leads to the harmful myocardial remodeling