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Description

Preclinical in vivo study of new insulin-like growth factor-I receptor-specific inhibitor in Ewing's sarcoma

It reduces inflammation mediated by IL-6, IL-12, and TNF- through the TLR4/NF-B pathway and ameliorates intestinal mucosal injury

PSPH amp GBM 1919 cells showed higher synthesis of AMP, GTP, CDP, CTP, and UMP, whereas PSPH V116I GBM 1919 cells exhibited enhanced synthesis of CDP and CTP (Fig