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Acknowledgements This work was supported by the Live Cell Imaging Laboratory at the Snyder Institute in the University of Calgary, and the Intestinal Inflammation Tissue Bank (IITB) at the University of Calgary

The POI was eluted with SAC buffer supplemented with 2.5 mM D-desthiobiotin

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Constipation is less dose-dependent and can persist, making it a more durable reason for discontinuation in patient reports. Sulfur burps reflect food sitting longer in a slowed stomach. Fatigue ranks second only to nausea in patient forums, although much of it tracks the calorie deficit rather than tirzepatide itself. Fried or fatty foods, coffee, meat, and alcohol can also become less appealing

The data is genuinely impressive

Kuijper, I