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The key challenges include high production costs, low yield, high voltage requirements, clogging, and the use of toxic materials in complex techniques

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In addition, icaritin upregulates CXC chemokines (e.g., CXCL9 and CXCL10) and T cell marker factors (e.g., CD8 and IFN- ), facilitating the recruitment of immune cells to tumors, and formed a "hot" tumor microenvironment in lung cancer (Lewis) cells [713]